Liverpool and Chelsea put domestic duties to one side as they bid to book their place in the UEFA Champions League quarter-finals.
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More than a few Anfield sceptics have labelled Rafa Benitez a dead man walking and if indeed this is the case, the Spaniard may call on the ghosts of European glories past to help his side against Internazionale.
Benitez's regime on Merseyside has encompassed middling mediocrity in domestic chores but in the splendour of European surrounds, Liverpool have proved to be sophisticates of some accomplishment.
In Monday's pre-match press conference Benitez looked like a man weighed down with all the worries in the world, but on being challenged as to whether the Inter tie would be his last should his side succumb to Italian charms, he bristled with indignation and a steely resolve returned as he challenged those journalists present to name the coaches that had reached two Champions League finals in three years.
In chasing a third appearance as Reds boss, Benitez will have to overcome the perennial underachievers Inter, who like an adult who refuses to leave the family nest, reign supreme in the bosom of their home(land) but are useless away from it.
Roberto Mancini's side have lost just once in 59 Serie A games and top their domestic table by 11 points from Roma. On paper this should see them installed as firm favourites to progress, but then on paper, Barnsley don't win at Anfield.
The spectre of Jose Mourinho at Chelsea dims with every victory under Avram Grant, but what remains is a ruthless efficiency that allows the West Londoners to claim wins in the manner of all true champions: without playing well.
Roman Abramovich craves beautiful football and while that served up by Grant is more cava than champagne, it will almost certainly be good enough to quietly snuff out Olympiakos' threat with minimum fuss.
Talismans Frank Lampard and John Terry have both returned in the past week to swell Grant's pool of talent and while their Greek hosts will be backed by a hostile and partisan home faithful, Chelsea will expect nothing less than a decent result to take back to Stamford Bridge.
With a Carling Cup final against Tottenham peeping over the horizon the ordinary one may choose to shuffle his pack from that which disposed of Huddersfield on Saturday, with an intriguing subplot being whether he elects to pair the effervescent Nicolas Anelka with the rampaging Didier Drogba for the first time.
Real Madrid travel to the Eternal City without a clutch of their defensive stalwarts but confident in the knowledge that their attack has been Gillette-sharp all season, and they should pose questions for Luciano Spalletti's Roma side.
The Giallorossi are able to welcome back favourite son Francesco Totti but the playmaker will be far from at his peak given a catalogue of injuries of late.
It would be hard to bill Schalke's game against Porto as anything but a battle of the also-rans, given the calibre of the other sides left in the competition.
However, the Portuguese club's rich Champions League history suggests they will be confident of claiming a quarter-final spot at the expense of their Bundesliga opponents.
Click below for individual previews
Liverpool v Internazionale
Olympiakos v Chelsea
Roma v Real Madrid
Schalke v Porto