Boro v Man Utd preview
Watch all the action, live on Sky Sports 1, from 1pm on Sunday
Middlesbrough are the latest team charged with the task of derailing the Manchester United juggernaut, live on Sky Sports 1.
The reigning champions are hurtling towards another Premier League title after six successive wins and are still playing entertaining football.
But Boro have a fair record against United and have also been performing creditably against the top-flight's 'big four' this season.
Boro have beaten Arsenal at home and drew away at Emirates Stadium as well as claiming a 1-1 draw against Liverpool at the Riverside.
Last weekend, Gareth Southgate's side were unlucky to lose 1-0 at Chelsea as Boro struck the woodwork on three occasions.
Southgate could stick with the team which started at Stamford Bridge as centre-half Robert Huth continues to battle against a foot injury.
Mido, who would have been suspended for this game in any case, is out for the season after a hernia operation, so Tuncay Sanli and Jeremie Aliadiere should start in attack.
Luke Young and Lee Cattermole shrugged off knocks to start against Chelsea, while record signing Afonso Alves appeared as a substitute after a hamstring complaint.
Boro's options are boosted by the return from suspension of Fabio Rochemback and he will press Cattermole and George Boateng for a place in central midfield.
United took a giant stride towards a place in the UEFA Champions League semi-finals in midweek with a 2-0 win at Roma thanks to goals from Cristiano Ronaldo and Wayne Rooney, although the victory did come at a price.
Nemanja Vidic suffered a knee injury against Roma and will miss the next two to three weeks of United's quest for trophies.
John O'Shea replaced Vidic at the Stadio Olimpico, although the Irishman could start at right-back on Sunday, with Wes Brown moving to the centre.
Mikael Silvestre was on the bench in Rome for the first time since suffering a knee injury in September and he is in contention, while skipper Gary Neville is also not far away after over a year without a first-team game.
Darren Fletcher, who has a good goalscoring record at the Riverside, is out with a knee injury, while Louis Saha is still missing with a hamstring problem.
Nani has sat out the last two matches with a minor injury, but Ryan Giggs could return after being left on the bench, in favour of Park Ji-sung, against Roma.
Carlos Tevez will hope to return to the starting line-up, while Owen Hargreaves is another who could be recalled by Sir Alex Ferguson.